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. 2016 Apr 22;17:16. doi: 10.1186/s12868-016-0250-2

Table 1.

Confirmed hits from the NCC library screen

Known mechanism of action	Compound	EC₅₀ μM^b_avg
Kinase inhibitor	Imatinib mesylate	1.4
Anti-cholinergic	Atracurium Besylate	5.3
Mitotic inhibitors	Docetaxel	0.1
	Methotrexate	0.1
	Tegafur	2.7
	Artesunate	3.3
Ion channels	Zu-capsaicin	4.7
	Amiloride	8.9
	Oxcarbazepine	14.7
Na²⁺/K⁺ ATPase inhibitor	Digoxin	11.3
γ-secretase inhibitors	LY 411, 575^a	0.00053
	BMS 708, 163^a	0.067
	MRK 560^a	0.082
	DAPT^a	0.55

^aCompounds not part of the NCC library screen

^bN = ≥ 2