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Bleeding produced by anti-fVIII MAbs in a murine tail snip model. Hemophilia A mice were injected with 0.5 mg/kg MAb, corresponding to peak plasma concentrations of 65 nM, followed by either 180 or 360 U/kg rBDD fVIII, corresponding to peak plasma concentrations of 2.5 and 5.0 nM, respectively. Medians and interquartile ranges are shown. The asterisk indicates MAbs with significantly more bleeding than control mice treated with fVIII but no MAb. *P < .05, Mann-Whitney U test.
