Table II.

Effects of nitroxoline on 5637 cell bladder cancer orthotopic xenografts in nude mice.

	Drug administration			Anti-cancer activity		Toxicity
Drug	Dose, mg/kg	Schedule	Route	Tumor weight, mga	Inhibition rate, %	Body weight loss, %a	Mortalities/total mice, n
Control	Vehicle	BID for 21 days	p.o.	164±61		14.8±4.9	4/14
Cisplatin	5	QW for 3 weeks	i.v.	79±41c	52.0	19.8±9.1	2/14
Nitroxoline	30	BID for 21 days	p.o.	88±32b	46.4	14.9±3.7	1/7
Nitroxoline	60	BID for 21 days	p.o.	63±24c	61.4	12.0±3.8	2/14
Nitroxoline	120	BID for 21 days	p.o.	50±21c	69.6	7.4±3.2	5/14
Nitroxoline	240	BID for 21 days	p.o.	43±19c	73.6	12.2±4.7	2/7

^aData are presented as mean ± standard deviation.

^bP<0.01

^cP<0.001 vs. vehicle control (one-way analysis of variance with Tukey's post-hoc test). BID, twice a day; QW, once a week; p.o., oral; i.v. intravenous.