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. Author manuscript; available in PMC: 2016 Jun 21.
Published in final edited form as: Nature. 2015 Dec 21;531(7593):196–201. doi: 10.1038/nature16446

Figure 5. The voltage sensing domains.

Figure 5

a, Partial S4 sequence alignment and arginine registry. b, Locations of VSD1, VSD2 and IIS4–S5 linker regions in AtTPC1. c, Side view of VSD1 with S1 omitted for clarity - same for VSD2. d, G-V curves of wild type AtTPC1 and neutralization mutations of arginines on IS4 and IIS4. e, Structure of VSD2 (left) and its surface rendered cross section (right). Grey double arrows indicate the three segments of the curved IIS4 helix. Arginine in the gating charge transfer center is labeled in red. f, Acute-angled connection between IIS4 and IIS4–S5 linker and the extensive interactions between the linker and IIS6. For clarity, the channel in b is rotated about 40° around the indicated axis.