Table 2. Mean values (SD) of frequency domain optical coherence tomography parameters of peripapillary RNFL thickness and full and inner macular thickness (in μm), with areas under the receiver operating characteristic curves (AUC) and sensitivities at fixed specificities.
| Parameter | Alzheimer’s disease (n = 45) | Controls(n = 48) | p* | AUC (SE) |
|---|---|---|---|---|
| Peripapillary RNFL | ||||
| Average thickness | 93.75 (13.42) | 102.96 (9.19) | <0.001 | 0.70 (0.05) |
| Superior | 110.88 (19.76) | 122.12 (15.55) | 0.01 | 0.66 (0.06) |
| Temporal | 66.91 (15.66) | 72.69 (9.16) | 0.07 | 0.59 (0.06) |
| Inferior | 112.38 (23.25) | 130.10 (12.78) | <0.001 | 0.77 (0.05) |
| Nasal | 82.64 (17.82) | 86.46 (13.61) | 0.34 | 0.56 (0.06) |
| Macula (full thickness) | ||||
| Average thickness | 257.89 (17.11) | 273.45 (13.14) | <0.001 | 0.74 (0.05) |
| Superior inner | 279.86 (21.10) | 303.75 (13.45) | <0.001 | 0.82 (0.05) |
| Temporal inner | 269.84 (18.31) | 293.45 (15.86) | <0.001 | 0.83 (0.04) |
| Inferior inner | 270.17 (20.61) | 300.10 (17.03) | <0.001 | 0.86 (0.04) |
| Nasal inner | 281.75 (20.65) | 308.12 (16.25) | <0.001 | 0.83 (0.04) |
| Superior outer | 251.80 (20.35) | 264.08 (14.78) | 0.01 | 0.68 (0.06) |
| Temporal outer | 242.15 (17.33) | 255.52 (14.79) | 0.001 | 0.72 (0.05) |
| Inferior outer | 252.26 (19.60) | 260.62 (17.16) | 0.089 | 0.62 (0.06) |
| Nasal outer | 246.60 (21.51) | 280.50 (15.55) | 0.02 | 0.70 (0.05) |
| Fovea | 221.38 (27.86) | 246.62 (25.26) | 0.001 | 0.75 (0.05) |
| Macula (inner layer) | ||||
| mRNFL | 32.51 (5.96) | 34.77 (3.12) | 0.06 | 0.60 (0.06) |
| GCL+ | 63.24 (7.60) | 69.00 (6.09) | 0.003 | 0.71 (0.05) |
| GCL++ | 95.66 (11.69) | 103.85 (7.73) | 0.002 | 0.72 (0.05) |
* = Generalized estimated equations. Significant values are in italics.