Table 1. Characteristics of the mice.
| Study 1 | Study 2 | Study 3 | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Ab Species | Rabbit | Mouse | Mouse | |||||||
| Dose | 10 mg/kg, 2/week | 5 mg/kg, 3/week | 0.3 mg/kg, 3/week | 5 mg/kg, 3/week | ||||||
| Infusion | AngII | Saline | AngII | AngII | ||||||
| Antibody | IgG Control | TGF-β | IgG Control | TGF-β | IgG Control | TGF-β | IgG Control | TGF-β | IgG Control | TGF-β |
| N | 9 | 10 | 10 | 10 | 20 | 20 | 10 | 10 | 10 | 10 |
| Basal BW (g) | 24.4±0.5 | 24.7±0.5 | 26.6±0.6 | 26.3±0.3 | 25.8±0.3 | 26.0±0.4 | 23.7±0.3 | 23.6±0.6 | 25.0±0.5 | 24.4±0.5 |
| End point BW (g) | 28.2±0.6 | 27.9±0.4 | 31.1±0.5 | 31.0±0.6 | 27.6±0.4* | 27.6±0.6* | 26.8±0.3 | 27.1±0.4 | 27.8±0.7 | 27.2±0.6 |
| Renin (ng/ml) | 1.2±0.1 | 1.1±0.0 | 2.3±0.3 | 2.1±0.3 | 1.3±0.03* | 1.2±0.03* | ND | ND | ND | ND |
| Platelet (103/μl) | 650±81 | 693±143 | 838±45 | 830±35 | 796±37 | 905±65 | 723±86 | 725±28 | 757±47 | 711±57 |
Study #1: TGF-β inhibition on AngII-infused aneurysms using a rabbit polyclonal TGF-β antibody.
Study #2: TGF-β inhibition on AngII-infused aneurysms using a mouse monoclonal TGF-β antibody
Study #3: TGF-β inhibition on AngII-infused aneurysms using a low or high dose of a mouse monoclonal TGF-β antibody
AngII = Angiotensin II; BW = body weight
*P<0.05, compared to saline groups by two-way ANOVA test. ND, not determined.