Table 1. Average type 1 error rates of the statistic for testing interaction between two genes with no marginal effect consisting only rare variants with 5 traits over random selected 50,000 pairs of genes from whole exome.

Sample Size	0.05	0.01	0.001
1000	0.0784	0.0188	0.0019
2000	0.0693	0.0097	0.0016
3000	0.0617	0.0135	0.0010
4000	0.0591	0.0126	0.0014
5000	0.0546	0.0095	0.0012