Table 5. P-values of top 30 pairs of significantly interacted genes with HDL and LDL after adjusting for sex, age and population stratification via five PCs.
| Gene 1 | Chr | Gene 2 | Chr | P-values | ||||
|---|---|---|---|---|---|---|---|---|
| Two Traits | HDL | LDL | ||||||
| MFRG | Pair-wise | PCA | FRG | FRG | ||||
| (minimum) | ||||||||
| SHPK | 17 | ST20 | 15 | 1.42E-19 | 4.30E-04 | 3.03E-02 | 2.36E-08 | 6.48E-11 |
| STK3 | 8 | CSMD1 | 8 | 5.98E-16 | 5.58E-04 | 1.76E-01 | 2.82E-07 | 6.06E-05 |
| ST20 | 15 | FRMD5 | 15 | 6.97E-15 | 7.14E-04 | 2.13E-03 | 9.36E-07 | 4.03E-07 |
| C5orf64 | 5 | PSMD1 | 2 | 9.81E-15 | 1.21E-05 | 2.64E-01 | 1.01E-06 | 3.75E-07 |
| ST20 | 15 | PDE4DIP | 1 | 3.65E-14 | 3.42E-06 | 2.18E-01 | 1.88E-03 | 1.95E-08 |
| SHPK | 17 | CSMD1 | 8 | 2.44E-13 | 2.37E-04 | 4.91E-05 | 1.26E-03 | 2.93E-04 |
| C5orf64 | 5 | SPRY1 | 4 | 2.64E-13 | 1.21E-05 | 2.94E-03 | 1.12E-06 | 1.67E-07 |
| NARG2 | 15 | CSMD1 | 8 | 3.77E-13 | 8.07E-05 | 4.74E-02 | 2.24E-03 | 1.11E-04 |
| SIGLEC7 | 19 | NBPF1 | 1 | 4.03E-13 | 6.34E-04 | 2.64E-02 | 5.04E-06 | 5.90E-07 |
| SHPK | 17 | NRG1 | 8 | 5.33E-13 | 3.91E-04 | 3.73E-03 | 2.48E-04 | 1.58E-07 |
| PLTP | 20 | NBPF1 | 1 | 8.35E-13 | 2.03E-03 | 2.03E-01 | 6.77E-06 | 6.34E-05 |
| DIAPH3-AS1 | 13 | SPRY1 | 4 | 1.06E-12 | 1.35E-05 | 5.48E-04 | 1.35E-04 | 1.34E-06 |
| MPG | 16 | NBPF1 | 1 | 1.11E-12 | 3.77E-03 | 5.56E-01 | 3.34E-04 | 2.18E-07 |
| FRMD5 | 15 | SLC8A3 | 14 | 2.92E-12 | 7.85E-05 | 9.79E-04 | 2.99E-03 | 1.67E-08 |
| DIAPH3-AS1 | 13 | PPRC1 | 10 | 3.57E-12 | 9.90E-04 | 7.71E-01 | 3.33E-05 | 2.01E-06 |
| DIAPH3-AS1 | 13 | STK3 | 8 | 3.57E-12 | 3.64E-03 | 4.74E-01 | 1.82E-06 | 5.95E-05 |
| CD300A | 17 | CSMD1 | 8 | 3.89E-12 | 3.19E-04 | 2.59E-01 | 3.65E-04 | 1.71E-04 |
| RNF40 | 16 | DIAPH3-AS1 | 13 | 4.09E-12 | 3.39E-03 | 2.68E-01 | 5.05E-05 | 1.37E-07 |
| CGB2 | 19 | CSMD1 | 8 | 4.38E-12 | 1.82E-04 | 3.19E-04 | 1.87E-05 | 5.23E-06 |
| SHPK | 17 | RYR3 | 15 | 4.47E-12 | 3.25E-04 | 2.47E-05 | 1.14E-02 | 7.29E-05 |
| FRMD5 | 15 | C5orf64 | 5 | 4.75E-12 | 1.42E-02 | 3.65E-01 | 8.14E-06 | 4.60E-05 |
| PPM1A | 14 | CSMD1 | 8 | 4.77E-12 | 6.84E-05 | 2.37E-03 | 1.09E-06 | 2.46E-05 |
| CSMD1 | 8 | ZBTB47 | 3 | 5.53E-12 | 4.02E-06 | 2.71E-04 | 9.85E-07 | 1.78E-03 |
| ST20 | 15 | PSMD1 | 2 | 5.75E-12 | 1.06E-05 | 9.13E-02 | 4.41E-06 | 4.93E-06 |
| CSMD1 | 8 | KIF3A | 5 | 6.56E-12 | 9.52E-04 | 2.35E-02 | 7.04E-03 | 1.16E-02 |
| TRIM22 | 11 | SORCS2 | 4 | 6.62E-12 | 1.05E-04 | 2.01E-01 | 2.98E-07 | 1.52E-05 |
| CREBBP | 16 | CSMD1 | 8 | 7.56E-12 | 2.64E-05 | 2.77E-12 | 2.78E-03 | 3.16E-03 |
| ADRA1B | 5 | PSMD1 | 2 | 9.05E-12 | 1.08E-05 | 5.86E-01 | 1.70E-05 | 1.04E-05 |
| TRIM22 | 11 | STK3 | 8 | 1.17E-11 | 3.46E-04 | 5.43E-02 | 1.48E-06 | 6.03E-05 |
| DIAPH3-AS1 | 13 | SH2B3 | 12 | 1.25E-11 | 5.62E-04 | 3.94E-01 | 5.91E-06 | 6.44E-05 |