Table 3. Reported studies of PD-L1 in NSCLC.

Author	Year	N	Population	PDL1 assay	PD-L1%	Cutoff %	Findings
Taube [31]	2014	41	Mixed histology	5H1, M3	53	5	Associated with TILsPredict response to chemotherapy
Azuma[44]	2014	164 NSCLC	Asian57% EGFR mutated Stage I-III	Lifespan Bio-sciences		Median	Associated with AC histology & EGFR mutation.
Konishi[40]	2004	52	Asian Stage I-III	M1H1		Median	No relationship to clinical outcomes observed
Kim[45]	2015	331 SCC	Asian Stage I-III	Cell Signalling	27	10	Correlated with CD8+ TILs Not associated with survivalCD8+ TILs correlated with improved survival
D’Incecco[33]	2015	125 NSCLC	Stage IVItalian	Abcam	55	5	Associated with AC histology, EGFR mutation.
Boland[46]	2013	214SCC	Caucasian Stage I-IV	Dako	19	1	No relationship to clinical outcomes observed.
Zhang[30]	2014	143 AC	Asian Stage I-III	Sigma-Aldrich		Median	Worse survival outcomes if PD-L1 positive
Velcheti[41]	2013	544 NSCLC	2 cohorts Caucasian & Greek Stage I-IV	Dr. Lieping Chen’s lab (5H1)	26, 35		Correlated with TILs Improved OS with PD-L1 expression (independent)
Yang[47]	2014	163 AC	Stage I Asian	Proteintech	40	5	Improved DFS PD-L1 positive No improved OS but very few deaths
Cooper[42]	2015	681 NSCLC	Caucasian Stage I-III	Merck	8	50	Improved OS PD-L1 positive in SCC, not in AC.
Schmidt	2015	321 NSCLC	Caucasian Stage I-III	Cell Signalling	24	5	Improved OS PD-L1 positive in SCC, adjuvant therapy, T2-T4 and N1-N3 disease.

AC adenocarcinoma; SCC squamous cell carcinoma; NSCLC non-small cell lung cancer; OS overall survival; DFS disease free survival; EGFR epidermal growth factor receptor; TILs tumor infiltrating lymphocytes.