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. 2016 Apr 22;11(4):e0153806. doi: 10.1371/journal.pone.0153806

Fig 3. Collagen fibril nanoscale morphology and mechanical properties in diabetic skin.

Fig 3

(A) Nanoscale collagen fibrils were imaged by atomic force microscopy (AFM). The white and red arrow heads indicate intact and fragmented/disorganized collagen fibrils, respectively. Images are representative of nine subjects. (B) Three-dimensional nanoscale collagen fibrils were imaged by AFM. Images are representative of nine subjects. (C) Collagen fibril roughness was analyzed using Nanoscope Analysis software (Nanoscope_Analysis_v120R1sr3, Bruker-AXS, Santa Barbara, CA). Results are expressed as the mean ± SEM, N = 6, *p<0.05. (D) Tensile strength, (E) traction forces, and (F) deformation were determined by AFM PeakForceTM Quantitative NanoMechanics mode and Nanoscope Analysis software. Means±SEM. N = 8, *p<0.05.