Table 1. Baseline.
| All, n = 8,342 | Quartile 1, n = 2,046 | Quartile 2, n = 1,899 | Quartile 3, n = 2,090 | Quartile 4, n = 2,307 | p | |
|---|---|---|---|---|---|---|
| Age, years (n), median (IQR) | (8342), 66 (58/74) | (2046), 52 (46/55) | (1899), 62 (60/64) | (2090), 70 (68/71) | (2307), 78 (76/81) | <0,0001 *†‡§¶# |
| Gender | <0.0001 *द# | |||||
| - Female, n (%) | 2944 (35) | 545 (27) | 534 (28) | 737 (35) | 1,128 (49) | |
| - Male, n (%) | 5398 (65) | 1501 (73/73/28) | 1365 (72/72/25) | 1353 (65/65/25) | 1179 (51/51/22) | |
| Height, cm (n), Median (IQR) | (6415), 171 (165/178) | (1575), 173 (166/180) | (1803), 173 (166/178) | (1616), 170 (165/176) | (1421), 168 (160/173) | <0.0001 †‡§¶# |
| Weight, kg (n), Median (IQR) | (6437), 80 (70/90) | (1577), 82 (71/94) | (1807), 83 (74/92) | (1621), 80 (71/90) | (1432), 74 (66/82) | <0.0001 †‡§¶# |
| Body-Mass-Index, kg/m2 (n), Mean±SD | (5712), 27.7±5 | (1565), 27.7±5 | (1540), 28.3±5 | (1372), 27.8±4 | (1235), 26.6±4 | <0.0001 *‡§¶# |
| Heart rate, bpm (n), Median (IQR) | (5366), 68 (60/78) | (1472), 69 (60/79) | (1440), 67 (60/78) | (1310), 68 (60/77) | (1144), 68 (60/78) | <0.246 |
| Arterial hypertension, n (%) | 4981 (70) | 1027 (56) | 1397 (71) | 1368 (78) | 1189 (75) | <0.0001 *†‡§¶# |
| Systolic blood pressure, mmHg (n), Median (IQR) | (5213), 135 (120/150) | (1415), 130 (120/140) | (1409), 134 (121/149) | (1264), 139 (125/150) | (1125), 140 (125/150) | <0.0001 *†‡§¶ |
| Diastolic blood pressure, mmHg (n), Median (IQR) | (5213), 80 (70/85) | (1415), 80 (70/88) | (1409), 80 (70/88) | (1264), 80 (70/85) | (1125), 74 (66/80) | <0.0001 †‡§¶# |
| Diabetes mellitus | ||||||
| - NIDDM, n (%) | 1255 (18) | 198 (11) | 363 (19) | 352 (20) | 342 (22) | <0.0001 *†‡¶ |
| - IDDM, n (%) | 522 (7) | 103 (6) | 138 (7) | 155 (9) | 126 (8) | 0,002 †‡§ |
| Hyperlipidemia, n (%) | 5026 (70) | 1171 (64) | 1492 (76) | 1311 (74) | 1052 (66) | <0.0001 *†¶# |
| Total cholesterol, mg/dl (n), Median (IQR) | (2489), 185 (155/217) | (595), 192 (158/222) | (666), 191 (160/221) | (627), 178 (154/212) | (601), 178 (150/213) | <0.0001 †‡§¶ |
| HDL, mg/dl (n), Median (IQR) | (1551), 47 (39/57) | (357), 45 (38/54) | (424), 47 (39/59) | (391), 48 (39/57) | (379), 48 (40/59) | 0.003 *‡ |
| LDL, mg/dl (n), Median (IQR) | (1562), 113 (86/141) | (363), 121 (92/151) | (425), 116 (88/142) | (392), 110 (83/138) | (382), 106 (83/133) | 0.002 †‡ |
| Serum-creatine,mg/dl (n), Median (IQR) | (2948), 1.03 (0.89/1.21) | (872), 0.95 (0.85/1.09) | (738), 1.02 (0.89/1.18) | (708), 1.05 (0.92/1.22) | (630), 1.14 (0.95/1.37) | <0.0001 *†‡¶# |
| Creatine-clearance **, ml/min (n), Median (IQR) | (2611), 79 (59/100) | (872), 98 (74/120) | (738), 82 (65/99) | (708), 70 (55/84) | (630), 49 (35/61) | <0.0001 *†‡§¶# |
| Smoker* | ||||||
| - current, n (%) | 1208 (17) | 556 (30) | 382 (20) | 183 (10) | 87 (6) | <0,0001 *†‡§¶# |
| - previous, n (%) | 1539 (22) | 349 (19) | 494 (25) | 402 (23) | 294 (19) | <0.0001 *†¶# |
| Family history, n (%) | 1220 (17) | 418 (23) | 324 (17) | 261 (15) | 217 (14) | <0.0001 *†‡¶ |
| Central vascular disease, n (%) | 893 (13) | 106 (6) | 217 (11) | 261 (15) | 309 (19) | <0.0001 *†‡§¶# |
| Peripheral vascular disease, n (%) | 710 (10) | 86 (5) | 175 (9) | 212 (12) | 237 (15) | <0.0001 *†‡§¶# |
| Prior myocardial infarction, n (%) | 1715 (24) | 329 (18) | 465 (24) | 454 (26) | 467 (29) | <0.0001 *†‡¶# |
| Prior PCI, n (%) | 1194 (17) | 225 (12) | 362 (19) | 357 (20) | 250 (16) | <0.0001 *†‡¶# |
| Prior coronary artery bypass graft, n (%) | 638 (9) | 60 (3) | 150 (8) | 206 (12) | 222 (14) | <0.0001 *†‡§¶ |
| Pacemaker, n (%) | 272 (4) | 21 (1) | 35 (2) | 71 (4) | 145 (9) | <0.0001 *†‡§¶# |
| CRT, n (%) | 16 (0.2) | 0 | 6 (0.3) | 5 (0.3) | 5 (0.3) | 0.134 |
| LVEF (levogram), % (n), Median (IQR) | (428), 56 (41/68) | (100), 60 (47/69) | (134), 58 (42/69) | (102), 55 (41/66) | (92), 51 (34/65) | 0.035 ‡ |
| NT-proBNP, pg/ml (n), Median (IQR) | (810), 595 (154/2259) | (208), 195 (72/1601) | (202), 373 (109/1417) | (183), 652 (251/2259) | (217), 1313 (406/4810) | <0.0001 ঠ|
| NYHA class | <0.0001 *†‡§¶# | |||||
| - Class I, n (%) | 4132 (58) | 1228 (67) | 1160 (59) | 978 (56) | 766 (48) | |
| - Class II-III, n (%) | 3017 (42) | 608 (33) | 798 (41) | 784 (45) | 827 (52) | |
| CCS class | <0.0001 *†‡§ | |||||
| - Class I, n (%) | 3508 (49) | 1001 (55) | 974 (50) | 804 (46) | 729 (46) | |
| - Class II, n (%) | 2160 (30) | 512 (28) | 577 (30) | 575 (33) | 496 (31) | |
| - Class III, n (%) | 1481 (21) | 323 (18) | 407 (21) | 383 (22) | 368 (23) |
** calculated with the Cockcroft-Gault formula.
Significant differences according to quartiles:
* = Q1 vs. Q2,
† = Q1 vs. Q3,
‡ = Q1 vs. Q4,
§ = Q2 vs. Q3,
¶ = Q2 vs. Q4,
# = Q3 vs. Q4.
Quartile 1 = <58 years;
Quartile 2 = 58–65 years;
Quartile 3 = 66–73 years;
Quartile 4 = >73 years.
Abbreviations:
CCS = canadian cardiovascular society;
CRT = cardiac resynchronization therapy;
HDL = high density lipoprotein;
IDDM = insulin dependent diabetes mellitus;
LDL = low density lipoprotein;
LVEF = left ventricular ejection fraction;
NIDDM = non insulin dependent diabetes mellitus;
NT-proBNP = n-terminal pro-brain natriuretic peptide;
NYHA = new york heart association;
p = p-value;
PCI = percutaneous coronary intervention.