Table 2. Candidate genes exclusively deregulated and targeted by human miR-541-3p.
| Microarray gene expressiona | PITA target gene predictions | |||||
|---|---|---|---|---|---|---|
| Gene | Gene function | Fold change | Nominal p-value | Adjusted p-value | minimum ΔΔG human variant | minimum ΔΔG non-human variant |
| KCTD11 | Potassium channel domain implicated in neuronal differentiation and tumor repression | -1.4 | 2.32E-03 | 4.12E-02 | -15.6 | -11.41 |
| SLC12A6 | K-Cl transporter involved in electrochemical equilibrium | -1.3 | 2.88E-03 | 4.82E-02 | -14.46 | -9.3 |
| PMP22 | Membrane protein component of myelin in peripheral nervous system | 1.3 | 1.68E-03 | 3.24E-02 | -13.04 | -8.28 |
| UQCC | Transmembrane protein involved in fibroblast growth factor regulation | 1.3 | 1.31E-04 | 4.54E-03 | -17.34 | -2.17 |
| TMEM183B | Transmembrane protein involved in cell interactions | 1.2 | 1.03E-03 | 2.25E-02 | -13.05 | -9.35 |
aDeregulated genes by the human miRNA compared with the negative control.