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Simplified view of the thiamine biosynthesis pathway in E.coli. Enzymes encoded by the thiC operon (thiC and thiF,S,G,H, dashed box) synthezise the primary substrates hydroxymethylpyrimidine phosphate (HMP-P) and hydroxyethylthiazole phosphate (HETP). AIR: Amino-imidazole ribotide. Note that thiE is in the same operon. Genes in the thiM operon (thiM and thiD in gray) code for kinases that ultimately produce HMP-PP. Adapted from.3
