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. Author manuscript; available in PMC: 2016 Apr 22.
Published in final edited form as: Invest New Drugs. 2013 May 25;32(1):25–36. doi: 10.1007/s10637-013-9979-y

Fig. 5.

Fig. 5

Ring-DIMs increase the activity of the initiator caspase-9 in AD and AI prostate cancer cells. Activity of caspase-9 was measured by cleavage of the fluorogenic substrate Ac-LEHD-AFC in response to a 24 h treatment of LNCaP cells (a) and PC-3 cells (b) with increasing concentrations (15–30 μM) of 4,4′-dibromoDIM (□), 7,7′-dibromoDIM (■), 4,4′-dichloroDIM (△), 7,7′-dichloroDIM (▲) or DIM (●)