Fig. 5.
The effect of HDAC inhibition on chemokine secretion in FP-treated BEAS-2B cells. BEAS-2B cells were incubated with FP (10−7 M) or DMA in the presence or absence of 100 nM TSA for 30 min. Cells were then stimulated with poly IC (50 μg/ml) for 24 h. Concentrations of CCL5/RANTES (a), CXCL8/IL-8 (b) and CXCL10/IP-10 (c) in the culture supernatants at 24 h were quantified by ELISA. The data are the mean ± SEM of 3 independent experiments. * p < 0.05 compared with DMA-treated cells in the presence or absence of TSA. n.s. = Not significant.