Table 3.

Regression models examining the relation between interarm differences in systolic blood pressure ≥ 10mmHg and brain injury on magnetic resonance imaging, across the entire sample and stratified by Apolipoprotein ε4 status.

		Whole sample			Apoe ε4−			Apoe ε4+
Outcome	Model	n	β ± SE*	P	n	β ± SE*	P	n	β ± SE*	P
TBV
	1	2174	−0.46 (0.17)	0.006	1665	−0.23 (0.19)	0.22	470	−1.30 (0.38)	0.0006
	2	2147	−0.43 (0.17)	0.01	1646	−0.21 (0.19)	0.26	463	−1.26 (0.38)	0.0009
WMHV
	1	2174	−0.04 (0.05)	0.46	1665	−0.02 (0.06)	0.70	470	−0.14 (0.11)	0.23
	2	2147	−0.04 (0.05)	0.43	1646	−0.01 (0.06)	0.80	463	−0.15 (0.11)	0.20
Silent cerebral infarcts
	1	2174	1.21 (0.86, 1.70)	0.27	1665	0.99 (0.66, 1.48)	0.95	470	2.06 (1.07, 3.99)	0.03
	2	2147	1.21 (0.86, 1.71)	0.27	1646	0.98 (0.65, 1.47)	0.91	463	2.14 (1.10, 4.19)	0.03

Model 1 adjusts for age, sex, systolic blood pressure in the left arm, age squared and time to MRI; model 2 additionally adjusts for the stroke risk factors outlined in the Framingham Stroke Risk Profile [5]. APOE = Apolipoprotein ε4 status, TBV = total brain volume, WMHV = white matter hyperintensity volume.

^*Odds ratio and 95% CI reported for silent cerebral infarcts.