Fig. 2.
Cytokine production in response to chTNT-3/CpG1585 and chTNT-3/CpG1826. a Pro-inflammatory (IL-6), b anti-inflammatory (IL-10), c TH17 (IL-17(F) and IL-23p19), and d TH1 (IL-12p40, IL-12p70, IL-2, and IFN-γ) cytokines released from murine splenocytes treated in vitro and measured using Luminex xMAP technology. Means were compared to the means of PBS-treated splenocytes with or without CD3 stimulation and adjusted for multiple comparisons using Dunnett’s method. chTNT-3, chTNT-3/sc-A, chTNT-3/sc-B corresponded to antibody concentrations of 83 µg/mL or oligo concentrations of 10 µg/mL. Error bars represent SEM. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001, n = 3, except IL-17(F) where n = 2 mice. CpG-A = CpG1585, CpG-B = CpG1826