Table 4.
Frequency of Animal-Specific EG Eye Global Change for each Parameter
| Parameter1 | Number of Rats Demonstrating EG Eye Change2 | Range of significant EG Eye Change (%)3 | ||
|---|---|---|---|---|
| + | - | + | - | |
| Neurovascular Canal | ||||
| BMO Radius (μm) | 5 | 0 | 5 ~ 13 (3 ~ 10) | 0 (0) |
| BMO Depth (μm)4 | 5 | 2 | 2 ~ 28 | −21 ~ −12 |
| ASCO Radius (μm) | 7 | 0 | 16~ 38 (8 ~ 21) | 0 (0) |
| ASCO Depth (μm) | 1 | 2 | 16 | −30 ~ −18 |
| PSCO Radius (μm)4 | 6 | 0 | 10 ~ 43 (5 ~ 21) | 0 (0) |
| PSCO Depth (μm)5 | 3 | 4 | 11 ~ 18 | −28 ~ −7 |
| Optic Nerve | ||||
| ON-ASCO Radius (μm) | 7 | 0 | 14 ~ 34 (11 ~ 30) | 0 (0) |
| ON-PSCO Radius (μm) | 6 | 0 | 9 ~ 43 (8 ~ 41) | 0 (0) |
| Optic Nerve to Scleral Canal Gap Distance | ||||
| ASCO-ON-ASCO Distance (μm) | 4 | 1 | 14 ~ 17 (18 ~ 26) | −12 (−13) |
| PSCO-ON-PSCO Distance (μm)4 | 2 | 2 | 14 ~ 28 (18 ~ 29) | −17~ −10 (−16 ~ −10) |
| Sclera/Choroid | ||||
| Scleral Thickness (μm)4 | 3 | 2 | 4 ~ 6 (4 ~ 5 ) | −9 ~ −7 (−8 ~ −7) |
| Scleral Depth (μm) | 4 | 1 | 6 ~ 10 | −10 |
| Choroidal Thickness (μm) | 2 | 6 | 4 ~ 19 (8 ~ 32) | −20 ~ −5 (−29 ~ −7) |
Only parameters in which multiple measurements per eye were possible were included in this analysis
Between eye comparison (EG versus control) was carried out for each parameter for each animal using generalized least squares model (GLS). Statistically significant between-eye differences were established at p<0.005 due to multiple comparisons. Positive sign (+) means increased, negative sign (−) means reduction.
The range of statistically significant EG eye change in micrometers. Percentage is in parentheses (expressed as the percent of the contralateral control Eye). Positive sign (+) means increased, negative sign (−) means reduction.
This parameter could only be measured in 7 of the 8 animals