Table 1.
Patient Demographics during their Index PEx Year Stratified by Prior-Year PEx.
| Prior-Year PEx | ||||||
|---|---|---|---|---|---|---|
| None (N=8,098) | One (N=2,457) | Two (N=1,466) | Three (N=762) | ≥ Four (N=796) | All (N=13,579) | |
| Age Group, N (%)* | ||||||
| <6 yrs | 1123 (13.9%) | 219 (8.9%) | 85 (5.8%) | 31 (4.1%) | 30 (3.8%) | 1488 (11.0%) |
| 6–12 yrs | 1840 (22.7%) | 460 (18.7%) | 215 (14.7%) | 106 (13.9%) | 83 (10.4%) | 2704 (19.9%) |
| 13–17 yrs | 1512 (18.7%) | 464 (18.9%) | 292 (19.9%) | 166 (21.8%) | 171 (21.5%) | 2605 (19.2%) |
| 18–24 yrs | 1462 (18.1%) | 580 (23.6%) | 407 (27.8%) | 223 (29.3%) | 281 (35.3%) | 2953 (21.7%) |
| 25–50 yrs | 1569 (19.4%) | 565 (23.6%) | 345 (23.5%) | 193 (25.3%) | 196 (24.6%) | 2868 (21.1%) |
| >50 yrs | 592 (7.3%) | 169 (6.9%) | 122 (8.3%) | 43 (5.6%) | 35 (4.4%) | 961 (7.1%) |
| FEV1 % Predicted Group, N (%)* | ||||||
| ≥100 | 1128 (13.9%) | 198 (8.1%) | 87 (6.0%) | 25 (3.3%) | 15 (1.9%) | 1453 (10.7%) |
| 70 to <100 | 3339 (41.2%) | 865 (35.2%) | 471 (32.1%) | 197 (25.9%) | 155 (19.5%) | 5027 (37.0%) |
| 40 to <70 | 1910 (23.6%) | 869 (35.4%) | 554 (37.8%) | 351 (46.1%) | 354 (44.5%) | 4038 (29.7%) |
| <40% | 610 (7.5%) | 299 (12.2%) | 255 (17.4%) | 151 (19.8%) | 227 (28.5%) | 1542 (11.4%) |
| NA, age <6 yrs | 984 (12.2%) | 191 (7.8%) | 71 (4.8%) | 28 (3.7%) | 25 (3.1%) | 1299 (9.6%) |
| NA, age ≥6 yrs | 127 (1.6%) | 35 (1.4%) | 28 (1.9%) | 10 (1.3%) | 20 (2.5%) | 220 (1.6%) |
| BMI kg/m2 | ||||||
| Mean (SD) | 20.1 (4.2) | 20.1 (4.0) | 20.5 (4.0) | 20.4 (3.7) | 20.1 (3.8%) | 20.1 (4.1) |
| N (%) | 8090 (99.9%) | 2452 (99.8%) | 1465 (99.9%) | 761 (99.9%) | 794 (99.7%) | 13562 (99.9%) |
| F508del Genotype, N (%)* | ||||||
| Homozygous | 4043 (49.9%) | 1243 (50.6%) | 724 (49.4%) | 381 (50.0%) | 401 (50.4%) | 6792 (50.0%) |
| Heterozygous | 2945 (36.4%) | 900 (36.6%) | 534 (36.4%) | 281 (36.9%) | 276 (34.7%) | 4936 (36.4%) |
| No F508del | 895 (11.1%) | 227 (9.2%) | 166 (11.3%) | 69 (9.1%) | 77 (9.7%) | 1434 (10.6%) |
| Genotype NA | 215 (2.7%) | 87 (3.5%) | 42 (2.9%) | 31 (4.1%) | 42 (5.3%) | 417 (3.1%) |
| Female Sex, N (%) | ||||||
| 4001 (49.4%) | 1314 (53.5%) | 826 (56.3%) | 442 (58.0%) | 464 (58.3%) | 7047 (51.9%) | |
| Medicaid Insurance, N (%)* | ||||||
| No | 5195 (64.2%) | 1428 (58.1%) | 818 (55.8%) | 386 (50.7%) | 328 (41.2%) | 8155 (60.1%) |
| Yes | 2840 (35.1%) | 1001 (40.7%) | 627 (42.8%) | 365 (47.9%) | 445 (55.9%) | 5278 (38.9%) |
| NA | 63 (0.8%) | 28 (1.1%) | 21 (1.4%) | 11 (1.4%) | 23 (2.9%) | 146 (1.1%) |
| Supplemental Ventilation, N (%)* | ||||||
| No | 7786 (96.1%) | 2325 (94.6%) | 1377 (93.9%) | 680 (89.2%) | 666 (83.7%) | 12834 (94.5%) |
| Yes | 137 (1.7%) | 72 (2.9%) | 49 (3.3%) | 57 (7.5%) | 92 (11.6%) | 407 (3%) |
| NA | 175 (2.2%) | 60 (2.4%) | 40 (2.7%) | 25 (3.3%) | 38 (4.8%) | 338 (2.5%) |
| Supplemental Feeding, N (%)* | ||||||
| No | 3272 (40.4%) | 956 (38.9%) | 536 (36.6%) | 270 (35.4%) | 205 (25.8%) | 5239 (38.6%) |
| Yes | 4641 (57.3%) | 1433 (58.3%) | 892 (60.8%) | 475 (62.3%) | 561 (70.5%) | 8002 (58.9%) |
| NA | 185 (2.3%) | 68 (2.8%) | 38 (2.6%) | 17 (2.2%) | 30 (3.8%) | 338 (2.5%) |
| Supplemental Oxygen, N (%)* | ||||||
| No | 7076 (87.4%) | 1998 (81.3%) | 1066 (72.7%) | 483 (63.4%) | 380 (47.7%) | 11003 (81.0%) |
| Yes | 866 (10.7%) | 407 (16.6%) | 360 (24.6%) | 254 (33.3%) | 386 (48.5%) | 2273 (16.7%) |
| NA | 156 (1.9%) | 52 (2.1%) | 40 (2.7%) | 25 (3.3%) | 30 (3.8%) | 303 (2.2%) |
| Smoker, N (%)* | ||||||
| No | 7482 (92.4%) | 2224 (90.5%) | 1290 (88.0%) | 663 (87.0%) | 684 (85.9%) | 12343 (90.9%) |
| Yes | 114 (1.4%) | 54 (2.2%) | 43 (2.9%) | 28 (3.7%) | 28 (3.5%) | 267 (2.0%) |
| NA | 502 (6.2%) | 179 (7.3%) | 133 (9.1%) | 71 (9.3%) | 84 (10.6%) | 969 (7.1%) |
| Second-Hand Smoke Exposure, N (%)* | ||||||
| No | 3879 (47.9%) | 1094 (44.5%) | 632 (43.1%) | 320 (42.0%) | 305 (38.3%) | 6230 (45.9%) |
| Yes | 1264 (15.6%) | 447 (18.2%) | 251 (17.1%) | 151 (19.8%) | 164 (20.6%) | 2277 (16.8%) |
| NA | 2955 (36.5%) | 916 (37.3%) | 583 (39.8%) | 291 (38.2%) | 327 (41.1%) | 5072 (37.4%) |
*
-column percentages; yrs = years; NA= covariate status not available