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. Author manuscript; available in PMC: 2016 Jun 1.
Published in final edited form as: Mol Imaging Biol. 2016 Jun;18(3):386–392. doi: 10.1007/s11307-015-0904-y

Fig. 3.

Fig. 3

[18F]PARPi in vivo pharmacokinetics. a In vivo blood half-life of [18F]PARPi (n=3). Blood was collected at different time points (5, 15, 30, 45, 60, 90, 120 min), weighted, and counted. Results expressed as percent injected dose per gram (%ID/g). b Selected tumor-to-non-target-tissues ratio of [18F]PARPi (n=12) calculated from biodistribution data. c Biodistribution study in selected tissues. After injection of [18F]PARPi into mice with tumor xenografts, mice were euthanized at 2 h post-injection and radioactivity in organs was measured (n=6/group). Error bars are mean±SD. P values were calculated with Student’s t-tests, unpaired; *P<0.05; **P<0.01; ***P<0.001; ****P<0.0001.