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. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: J Steroid Biochem Mol Biol. 2015 Oct 22;160:118–126. doi: 10.1016/j.jsbmb.2015.10.007

Figure 2. Gonadal hormones modulate the SCN and circadian rhythms.

Figure 2

A. Schematic representation of differences between the estrogenic versus androgenic inputs to the SCN. The SCN receives inputs from ER-rich (red) and AR-rich (blue) nuclei, including the retina, intergeniculate leaflet (IGL), and dorsal raphe (DR). DR projects to the SCN via the median raphe (left). B. Schematic showing the distribution of ER and AR in the SCN (see text for details). C. Representative actograms show free running locomotor activity of male and female mice housed in constant darkness before and after gonadectomy (GDX). The horizontal axis is 48 h and the vertical axis is consecutive days. Adapted from [33] with permission.