Table 3. Gene ontology terms enriched for genes differently expressed between tumourigenic and non-tumourigenic cell lines.
| Term | Ontology | Proportion of set that is differentially expressed | # Genes in set |
|---|---|---|---|
| mRNA cis splicing, via spliceosome | BP | 0.500 | 8 |
| Negative regulation of mRNA splicing, via spliceosome | BP | 0.364 | 11 |
| Somatic diversification of immune receptors via somatic mutation | BP | 0.333 | 6 |
| Somatic hypermutation of immunoglobulin genes | BP | 0.333 | 6 |
| Negative regulation of mRNA processing | BP | 0.308 | 13 |
| Establishment of mitochondrion localization, microtubule-mediated | BP | 0.286 | 7 |
| Mitochondrion transport along microtubule | BP | 0.286 | 7 |
| mRNA splice site selection | BP | 0.278 | 18 |
| Negative regulation of RNA splicing | BP | 0.267 | 15 |
| Aspartate transport | BP | 0.250 | 8 |
| C4-dicarboxylate transport | BP | 0.222 | 9 |
| Establishment of mitochondrion localization | BP | 0.222 | 9 |
| Regulation of transcription involved in G1/S phase of mitotic cell cycle | BP | 0.176 | 17 |
| Spliceosomal complex assembly | BP | 0.167 | 36 |
| Regulation of mRNA splicing, via spliceosome | BP | 0.129 | 31 |
| Spliceosomal snRNP assembly | BP | 0.125 | 32 |
| rRNA processing | BP | 0.123 | 73 |
| RNA export from nucleus | BP | 0.123 | 65 |
| Ribosome biogenesis | BP | 0.121 | 99 |
| mRNA transport | BP | 0.121 | 58 |
| Nucleic acid transport | BP | 0.120 | 75 |
| RNA transport | BP | 0.120 | 75 |
| Establishment of RNA localization | BP | 0.120 | 75 |
| rRNA metabolic process | BP | 0.114 | 79 |
| Termination of RNA polymerase II transcription | BP | 0.114 | 44 |
| Nuclear export | BP | 0.110 | 100 |
| RNA localization | BP | 0.110 | 82 |
| Ribonucleoprotein complex biogenesis | BP | 0.109 | 175 |
| mRNA export from nucleus | BP | 0.105 | 57 |
| Nucleobase-containing compound transport | BP | 0.095 | 95 |
| Ribonucleoprotein complex assembly | BP | 0.094 | 96 |
| Ribonucleoprotein complex subunit organization | BP | 0.088 | 102 |
| RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | BP | 0.083 | 206 |
| mRNA splicing, via spliceosome | BP | 0.083 | 206 |
| RNA splicing, via transesterification reactions | BP | 0.081 | 211 |
| RNA splicing | BP | 0.069 | 260 |
| ncRNA processing | BP | 0.069 | 145 |
| ncRNA metabolic process | BP | 0.065 | 231 |
| mRNA processing | BP | 0.058 | 291 |
| DNA replication | BP | 0.058 | 226 |
BP, biological process.