Table 1.

In vitro activity of compounds (1a–f) against intracellular Leishmania amastigotes and murine J774 macrophages

Compound	R	IC50a (nM)
Intracellular L. amazonensis	Intracellular L. donovani	J774 macrophages
1a	H	2100 ± 200	2400 ± 300	22,000 ± 4000
1b		130 ± 30	310 ± 10	13,000 ± 1000
1c		1100 ± 300	2100 ± 400	>20,000
1d		250 ± 10	340 ± 50	8500 ± 800
1e		900 ± 230b	1200 ± 100	>50,000
1f		2700 ± 200b	2600 ± 100	22,000 ± 1000

^aThe values are means ± standard errors of at least three independent experiments.

^bThe values are the means ± range of two independent experiments.