Skip to main content
. 2016 May 15;26(10):2551–2556. doi: 10.1016/j.bmcl.2016.03.082

Table 2.

In vitro activity of compounds 1b, 1g–i against intracellular Leishmania amastigotes and murine J774 macrophages

graphic file with name fx8.jpg

Compound R1 R2 IC50a (nM)
Intracellular L. amazonensis Intracellular L. donovani J774 macrophages
1b H H 130 ± 30 310 ± 10 13,000 ± 1000
1g H OCH3 820 ± 310 900 ± 150 6700 ± 900
1h H F 920 ± 190 1100 ± 100 8000 ± 100
1i OCH3 H 1400 ± 200 1300 ± 100 5300 ± 1000
a

The values are means ± standard errors of at least three independent experiments.