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. 2016 May 15;26(10):2551–2556. doi: 10.1016/j.bmcl.2016.03.082

Table 3.

In vitro activity of compounds 1b, 1j–n against intracellular Leishmania amastigotes and murine J774 macrophages

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Compound R1 R2 IC50a (nM)
Intracellular L. amazonensis Intracellular L. donovani J774 macrophages
1b OCH(CH3)2 H 130 ± 30 310 ± 10 13,000 ± 1000
1j H OCH(CH3)2 1600 ± 300 1400 ± 300 13,000 ± 1000
1k OCH(CH2)4 H 140 ± 10 170 ± 40 13,000 ± 3000
1l OCH2CH3 H 980 ± 70b 850 ± 170 6600 ± 600
1m OCH3 H 3700 ± 1300b 1400 ± 300 9000 ± 2000
1n CF3 H >10,000b 6100 ± 1400 >20,000
a

The values are means ± standard errors of at least three independent experiments.

b

The values are the means ± range of two independent experiments.