Table 4.
IC50 values (μM) of the cladribine and its analogues on HCL, TCL, and CLL a.
| Compound | HCL | TCL | CLL | |||
|---|---|---|---|---|---|---|
| ATP | 3H-Leu | ATP | 3H-Leu | ATP | 3H-Leu | |
| 12a | 0.065 | 0.090 | 0.020 | 0.039 | 0.004 | 0.011 |
| 12b | 0.81 | 0.85 | 4.81 | 9.40 | 1.33 | 0.88 |
| 13a | >33 | >33 | >33 | >33 | >33 | >33 |
| 13b | >32 | >32 | >32 | >32 | ND b | >32 |
| 14a | >32 | >32 | >32 | >32 | >32 | >32 |
| 14b | >30 | >30 | >30 | >30 | >30 | >30 |
| 15a | >29 | >29 | >29 | >29 | >29 | >29 |
| 15b | >28 | >28 | >28 | >28 | >28 | >28 |
| 16a | 11.5 | 16.3 | 9.6 | 9.0 | 4.3 | 5.4 |
| 16b | >27 | >27 | >27 | >27 | ND b | ND b |
| 17a | >28 | >28 | >28 | >28 | >28 | >28 |
| 17b | >27 | >27 | >27 | >27 | >27 | >27 |
| 18a | >27 | >27 | >27 | >27 | >27 | >27 |
| 18b | >26 | >26 | >26 | >26 | >26 | >26 |
| 21a | 0.76 | 0.96 | 0.13 | 0.16 | 0.13 | 0.14 |
| 21b | 1.8 | 7.2 | 8.6 | 10.2 | 2.0 | 4.0 |
a One patient per disease type; b ND = not determined.