Table 4.
Univariate and multivariate analyses of survival (DFS) among the 110 patients with ESOSCC according to the clinicopathological variables and the strong GalNAc-T3 expression
| Variables | No. of patients (%) | Univariate | Multivariate | |||||
|---|---|---|---|---|---|---|---|---|
| Disease-free | Disease | HR | 95 % CI | P value | HR | 95 % CI | P value | |
| Age | ||||||||
| ≦60 | 22 (68.8) | 10 (31.3) | 100 | |||||
| >60 | 51 (65.4) | 27 (34.6) | 1.26 | 0.61–2.62 | 0.53 | |||
| Sex | ||||||||
| Female | 31 (63.3) | 18 (36.7) | 1.00 | |||||
| Male | 42 (68.9) | 19 (31.1) | 0.85 | 0.45–2.30 | 0.25 | |||
| ECOG PS | ||||||||
| 0–1 | 64 (64.0) | 36 (36.0) | 1.00 | |||||
| 2–4 | 9 (90.0) | 1 (10.0) | 0.31 | 0.04–2.30 | 0.25 | |||
| Smoking | ||||||||
| (−) | 34 (66.7) | 17 (33.3) | 1.00 | |||||
| (+) | 39 (66.1) | 20 (33.9) | 1.08 | 0.56–2.06 | 0.82 | |||
| Alcohol | ||||||||
| (−) | 22 (68.8) | 10 (31.3) | 1.00 | |||||
| (+) | 51 (65.4) | 27 (34.6) | 1.55 | 0.79–3.00 | 0.20 | |||
| T stage | ||||||||
| T1 | 42 (71.2) | 17 (28.8) | 1.00 | |||||
| T2 | 31 (60.8) | 20 (39.2) | 1.53 | 0.80–2.91 | 0.20 | |||
| Tumor location | ||||||||
| Maxilla, mandible, buccal | 23 (65.7) | 12 (34.3) | 1.00 | |||||
| Tongue, floor of mouth | 50 (66.7) | 25 (33.3) | 1.20 | 0.50–2.40 | 0.82 | |||
| Differentiation | ||||||||
| Well, moderately | 68 (69.4) | 30 (30.6) | 1.00 | 1.00 | ||||
| Poorly | 5 (41.7) | 7 (58.3) | 2.53 | 1.11–5.79 | 0.03 | 0.69 | 0.19–2.54 | 0.58 |
| Mode of invasion | ||||||||
| 1, 2, 3 | 68 (71.6) | 27 (28.4) | 1.00 | 1.00 | ||||
| 4C, D | 5 (33.3) | 10 (66.7) | 3.29 | 1.59–6.82 | 0.001 | 3.23 | 1.02–10.6 | 0.05 |
| Vascular invasion | ||||||||
| v(−) | 70 (69.3) | 31 (30.7) | 1.00 | 1.00 | ||||
| v(+) | 3 (33.3) | 6 (66.7) | 3.54 | 1.47–8.52 | 0.01 | 2.25 | 0.87–5.78 | 0.09 |
| Lymphatic vessel invasion | ||||||||
| ly(−) | 68 (73.9) | 24 (26.1) | 1.00 | 1.00 | ||||
| ly(+) | 5(27.8) | 13 (72.2) | 3.96 | 1.98–7.91 | <0.001 | 2.18 | 1.01–4.71 | 0.05 |
| Perineural involvement | ||||||||
| ne(−) | 71 (66.4) | 36 (33.6) | 1.00 | |||||
| ne(+) | 2 (66.7) | 1 (33.3) | 0.87 | 0.12–6.34 | 0.89 | |||
| GalNAc-T3 expression | ||||||||
| Weak+ | 53 (75.7) | 17 (24.3) | 1.00 | 1.00 | ||||
| Strong+ | 20 (50.0) | 20 (50.0) | 2.81 | 1.47–5.37 | 0.002 | 2.23 | 1.06–4.80 | 0.03 |
v vascular invasion, ly lymphatic vessel invasion, ne perineural involvement