Table 1.
Cysteine Redox Isoforms of HMGB1 Detected in Synovial Fluid from Individual JIA Patients
| Cysteine redox modification | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| C23 | C45 | C106 | ||||||||||
| Patient | Subdiagnosis | Sex | HMGB1 (ng/ml) | SH | S-S | SOxH | SH | S-S | SOxH | SH | S-S | SOxH |
| 1 | Undiff. | F | 21 | + | − | − | + | − | − | + | − | + |
| 2 | Poly | F | 95 | + | + | − | + | + | − | + | − | + |
| 3 | Undiff. | F | 80 | + | + | − | + | + | − | + | − | + |
| 4 | Oligo | F | 27 | + | + | − | + | + | − | + | − | + |
| 5 | Oligo | M | 16 | + | + | − | + | + | − | + | − | + |
| 6 | Oligo | F | 20 | + | + | − | + | + | − | + | − | + |
| 7 | Poly | F | 98 | + | + | − | + | + | − | + | − | + |
| 8 | Oligo | F | 43 | + | + | − | + | + | − | + | − | + |
| 9 | Oligo | F | 58 | + | + | + | + | + | + | + | − | + |
| 10 | Oligo | M | 10 | + | + | + | + | + | + | + | − | + |
| 11 | Oligo | M | 23 | − | + | + | − | + | + | + | − | + |
| 12 | Oligo | M | 10 | − | + | + | − | + | + | + | − | + |
| 13 | Poly | M | 195 | − | + | + | − | + | + | + | − | + |
| 14 | Oligo | M | 15 | − | + | + | − | + | + | + | − | + |
| 15 | Oligo | M | 6 | − | + | + | − | + | + | + | − | + |
| 16 | Oligo | M | 6 | − | − | + | − | − | + | + | − | + |
| 17 | Oligo | M | 7 | − | − | + | − | − | + | + | − | + |
| Number of patients with given cysteine modification | 10 | 14 | 9 | 10 | 14 | 9 | 17 | 0 | 17 | |||
Patients are arranged after increasing oxidative cysteine status. Mass-spectrometric traces of peptides with indicated cysteine redox status are denoted by (+). The absence of mass-spectrometric traces of an indicated cysteine redox status is represented by (−). HMGB1, high mobility group box protein 1; JIA, juvenile idiopathic arthritis; undiff., undifferentiated.