Table 7. Diagnostic Indices of Whole-Body BMD Measurements for Diagnosis of Abnormal BMD and Osteoporosisa.
| Sen. (95% CI) | Spec. (95% CI) | PPV (95% CI) | NPV (95% CI) | PLR (95% CI) | NLR (95% CI) | Accuracy (95% CI) | Kappa (95% CI) | ||
|---|---|---|---|---|---|---|---|---|---|
| Abnormal T- Score (Osteopenia and Osteoporosis) vs. Normal | |||||||||
| Spine vs. WB | TP: 46, FN: 21, TN: 33, FP: 5 | 69 (57 - 80) | 87 (72 - 96) | 90 (79 - 97) | 61 (47 - 74) | 5.2 (2.3 - 12) | 2.8 (1.9 - 4) | 75 (66 - 83) | 0.51 (0.35 - 0.66) |
| Hip vs. WB | TP: 51, FN: 24, TN: 30, FP: 0 | 68 (56 - 78) | 100 (88 - 100) | 100 (93 - 100) | 56 (41 -69) | NA | 3.1 (2.2 - 4.3) | 77 (68 - 85) | 0.55 (0.41 - 0.69) |
| Forearm vs. WB | TP: 46, FN: 27, TN: 27, FP: 5 | 63 (51 - 74) | 84 (67 - 95) | 90 (79 - 97) | 50 (36 - 64) | 4. (1.8 - 9.2) | 2.3 (1.6 - 3.2) | 70 (60 - 78) | 0.40 (0.24 - 0.56) |
| Osteoporosis vs. Others | |||||||||
| Spine vs. WB | TP: 6, FN: 27, TN:68, FP: 4 | 18 (7 - 35) | 94 (86 - 98) | 60 (626 - 88) | 72 (61 - 80) | 3.3 (1 - 10.8) | 1.2 (1 - 1.4) | 70 (61 - 79) | 0.16 (0. - 0.33) |
| Hip vs. WB | TP: 8, FN: 16, TN: 79, FP: 2 | 33 (16 - 55) | 98 (91 - 99) | 80 (44 - 97) | 83 (74 - 90) | 13.5 (3.1 - 59.4) | 1.5 (1.1 - 1.9) | 83 (74 - 90) | 0.39 (0.17 - 0.60) |
| Forearm vs. WB | TP: 9, FN: 33, TN: 62, FP: 1 | 21 (10 - 37) | 98 (91 - 99) | 90 (56 - 99) | 65 (55 - 75) | 13.5 (1.8 - 102.8) | 1.3 (1.1 - 1.5) | 68 (74 - 90) | 0.23 (0.08 - 0.37) |
Abbreviation: TP, true positive; FN, false negative; TN, true negative; FP, false positive; Sen., sensitivity; Spec., specificity; PPV, positive predictive value; NPV, negative predictive value; PLR, positive likelihood ratio; NLR, negative likelihood ratio; BMD, bone mineral density; WB, whole body; CI, confidence interval.
aAll values are mentioned as percent except for PLR, NLR and Kappa.