FIGURE 3.

Heatmap of Gene Set Enrichment Analysis of Transcriptional Factor targets. The Western-style diet supplemented with vitamin D induced significant upregulation of VDR target genes (VDR, FDR-q val = 0.09) and target genes of other transcription factors that have key roles in immune response, proliferation, and extracellular matrix function. Addition of calcium reversed these changes toward baseline. Note that only the top significant pathways and categories are presented in the figure (FDR-q val < 0.01). For a full list of significantly enriched pathways, please refer to Supplemental Table 5. FDR-q val, false discovery rate adjusted significance (q value); VDR, vitamin D receptor.