Table 3.
Results of bioinformatics analyses on downregulated pathways in HUVECs after TGFβ1 (10 ng/mL) stimulation.
| Pathway analysis | Downregulated gene count | P value |
|---|---|---|
| Olfactory transduction | 405 | 0.0036241 |
| Apoptosis | 86 | 0.0050919 |
| PI3K-Akt signaling pathway | 346 | 0.006535 |
| mRNA surveillance pathway | 91 | 0.0082309 |
| Ribosome biogenesis in eukaryotes | 85 | 0.0119435 |
| Circadian rhythm | 30 | 0.0140969 |
| Chemical carcinogenesis | 80 | 0.0189201 |
| Ras signaling pathway | 227 | 0.0201366 |
| Melanoma | 71 | 0.0211199 |
| Hypertrophic cardiomyopathy (HCM) | 85 | 0.0284512 |
| Rap1 signaling pathway | 213 | 0.0320182 |
| Estrogen signaling pathway | 100 | 0.0381713 |
| Tight junction | 134 | 0.0382214 |
| Nicotinate and nicotinamide metabolism | 28 | 0.0382726 |
| Drug metabolism-cytochrome P450 | 68 | 0.0398014 |
| Serotonergic synapse | 114 | 0.0453301 |
| Neuroactive ligand-receptor interaction | 321 | 0.0459533 |
| Tyrosine metabolism | 39 | 0.0463610 |