Table 1.
Differentially expressed genes from insulin signaling pathway of Id2−/− mice. Genes with significant differences (p < 0.05) are shown in bold. Peak phase value (determined by Lomb-Scargle phase values within CIRCA) in circadian time (CT) is provided where gene was identified as a clock control gene. Rhythmic genes identified from CIRCA database of Mouse 1.OST Brown Adipose (Affymetrix).
| Insulin signaling array | Symbol | Refseq | All | Male | Female | Clock control gene-peak phase | |||
|---|---|---|---|---|---|---|---|---|---|
| Fold change | p value | Fold change | p value | Fold change | p value | ||||
| Gene name | |||||||||
| AE binding protein 1 | Aebp1 | NM_009636 | 1.9 | 0.09 | 1.6 | 0.03 | — | ||
| Complement factor D (adipsin) | Cfd | NM_013459 | 2.4 | 0.01 | 3.6 | 0.03 | — | ||
| Fructose bisphosphatase 1 | Fbp1 | NM_019395 | 1.3 | 0.22 | 1.6 | 0.05 | — | ||
| Glucose-6-phosphatase, catalytic | G6pc | NM_008061 | 1.5 | 0.28 | 1.5 | 0.33 | 1.6 | 0.02 | — |
| Growth factor receptor bound protein 10 | Grb10 | NM_010345 | 1.5 | 0.08 | — | ||||
| Insulin receptor substrate 1 | Irs1 | NM_010570 | 1.4 | 0.01 | 1.3 | 0.07 | 1.4 | 0.05 | — |
| Protein tyrosine phosphatase, receptor type, F | Ptprf | NM_011213 | 1.7 | 0.05 | 2.6 | 0.05 | — | ||
| Scr homology 2 domain containing transforming protein C1 | Shc1 | NM_011368 | 1.25 | 0.01 | — | ||||
|
| |||||||||
| Glucose-6-phosphatase, catalytic, 2 | G6pc2 | NM_021331 | −3.2 | 0.08 | — | ||||
| Insulin-like growth factor 2 | Igf2 | NM_010514 | −1.2 | 0.21 | −1.4 | 0.04 | — | ||
| V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog | Kras | NM_021284 | −1.1 | 0.09 | −1.25 | 0.03 | — | ||
| Protein kinase C, iota | Prkci | NM_008857 | −1.2 | 0.02 | −1.3 | 0.02 | CT0 | ||
| Thyroglobulin | Tg | NM_009375 | −1.8 | 0.29 | −3.5 | 0.02 | — | ||