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. Author manuscript; available in PMC: 2017 Apr 1.
Published in final edited form as: Exp Eye Res. 2016 Feb 13;145:269–277. doi: 10.1016/j.exer.2016.01.018

Figure 1. RPE mtDNA damage increases with AMD progression.

Figure 1

Long-extension PCR was used to determine mtDNA lesion frequency in RPE from human donor macula. Data were normalized to the mean of the non-disease age-matched controls (MGS1). Sample size for each group is provided on the graph. (A) Summary of donors from previous studies (Karunadharma et al., 2010; Terluk et al., 2015) used in the current analysis. (B) Graph of mtDNA damage for donors without AMD (MGS1) and donors with progressively more severe stages of AMD using donors from the combined data set. MGS groups were compared by one-way ANOVA and Tukey’s post hoc test. Significance was set at p<0.05. *P<0.001; MGS1 was less than MGS2, MGS3 and MGS4. Data are mean + SEM.