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Effects of 2-BFI, BU224 and CR4056 on formalin-induced flinching (n=6 per group). Vertical axis, total flinches during 0–10 min (phase 1, upper panel) and 20–60 min (phase 2, lower panel) following formalin treatment; horixontal axis, drug dose (mg/kg). * P < 0.05 as compared to vehicle control.
