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. Author manuscript; available in PMC: 2017 May 1.
Published in final edited form as: Gastroenterology. 2016 Feb 4;150(5):1196–1207. doi: 10.1053/j.gastro.2016.01.031

Figure 2. TRIM22 - NOD2 Network.

Figure 2

A) VEOIBD loci focused subnetwork within RISK Pediatric Crohn's ileum network.

To define the context of VEOIBD in the ileum network, genes known to be causally associated with VEOIBD (not including TRIM22) were projected onto the RISK network and extended out a path length of two. The resulting VEOIBD focused sub network is comprised of 665 genes and contains TRIM22 and NOD2. The TRIM22-NOD2 paths are highlighted in bold and are connected to the known VEOIBD loci CYBB, and STAT1, as well as the GWAS locus IRF8.

B) Local network structure surrounding the NOD2/TRIM22 paths in the 665-node VEOIBD focused subnetwork.

Representative nodes from the 179-gene TRIM22 network within the 665 node VEOIBD loci focused RISK subnetwork.

C) TRIM22-NOD2 interaction is conserved in the adult IBD intestine.

This network provides the context of the TRIM22/NOD2 interaction in the adult IBD intestine. The 179-gene TRIM22 network was projected and extended out an additional path length on the adult IBD pan intestine Bayesian network. IBD GWAS (green), VEOIBD loci (orange), IBD drug targets approved or in clinical development (red), and calprotectin (S100A8) (purple) are all represented in this conserved subnetwork.