Fig. 6. Sequences obtained from LIG4-deficient individuals show significantly reduced N nucleotide addition between joined V(D)J gene elements.
The percentage of unique sequences with indicated numbers of N nucleotides added are shown for TRB (a, b) and IGH (c, d). N1 nucleotides are added between V and D or V and J gene elements, and N2 nucleotides between D and J elements. No N nucleotide addition is indicated as 0, each 3 additional N nucleotides added are shown in one bar up to more than 16 (16+) N nucleotides; error bars indicate SD (* p≤0.05; ** p≤0.01).