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. Author manuscript; available in PMC: 2017 Mar 14.
Published in final edited form as: Xenotransplantation. 2016 Mar 14;23(2):137–150. doi: 10.1111/xen.12229

Figure 6.

Figure 6

Human PBMC proliferative response to GTKO/hCD46 and GTKO/hCD46/NeuGcKO pAECs and islet cells. CFSE-labeled human PBMC were cocultured with either GTKO/hCD46 or GTKO/hCD46/NeuGcKO pAECs at 1:10 ratio for 5 days. Similarly, human PBMC were cocultured with islet cells at 1:1 ratio. The proliferative response to pAECs and islet cells was weak. The response to GTKO/hCD46/NeuGcKO AECs was slightly weaker than to GTKO/hCD46 AECs, as was the response to the respective isolated islet cells. (Representative data from experiments using PBMCs from two different humans)