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. Author manuscript; available in PMC: 2017 Mar 14.
Published in final edited form as: Xenotransplantation. 2016 Mar 14;23(2):137–150. doi: 10.1111/xen.12229

Figure 7.

Figure 7

The effect of genetic modification on pAEC-induced human platelet aggregation. When human platelet aggregation associated with WT pAEC (54%) was compared with that to hAEC (4%), a significant difference was observed (***p<0.001). GTKO/hCD46 (42%) and GTKO/hCD46/NeuGcKO (39%) pAEC significantly reduced the aggregation compared to WT pAEC (*p<0.05), but aggregation remained significantly greater than to hAEC (**p<0.01). There was no significant difference in platelet aggregation between GTKO/hCD46 and GTKO/hCD46/NeuGcKO.