. Author manuscript; available in PMC: 2017 Apr 1.

Published in final edited form as: Exp Eye Res. 2015 Nov 22;145:68–74. doi: 10.1016/j.exer.2015.11.008

Table 1.

MANOVA comparisons
Effect of neurotrophic support
	B6+BDNF^* (n=6)	B6+anti-BDNF (n=8)	B6+SCL (n=12)	B6+SCL+BDNF^* (n=5)	B6.P301STau (n=6)
B6^* (n=23)	P = 0.06	P = 0.034	P < 0.0001	P = 0.1	P = 0.0006
B6+SCL (n=12)				P < 0.0001
Effect of genotype
	D2 (n=10)	D2.Gpnmb+ (n=12)
B6 (n=23)	P < 0.0001	P < 0.0001
D2 (n=10)		P = 0.0012

Legend. B6, control C57BL/6J; B6+SCL, lesion of the contralateral superior colliculus one month before; B6+BDNF, 2 weeks after intravitreal injection of BDNF; B6+SCL+BDNF, 2 weeks after intravitreal injection of BDNF in mice with lesion of the contralateral superior colliculus; B6.P301S Tau, mice transgenic for human mutant P301S Tau; B6+anti-BDNF, 2 weeks after intravitreal injection of anti-BDNF; D2, DBA/2J mice 4 months old; D2.Gpnmb+, mice coisogenic with D2 that have a Gpnmb gene with normal function.

An initial 2-factor analysis including B6, B6+BDNF, B6+SCL, and B6+SCL+BDNF identified a statistically significant interaction (p=0.005) of BDNF and SCL. Since these effects were not additive, the pairwise group comparisons appearing in this table were performed. Details appear in the text.