Table 4.

Results of regression analyses

Parameter at baseline (2-months)	Independent Variable	Estimate: gait speed change 2–12 months, m/s	Standard Error	p-Value
Model 1. Stroke type and locus, all available participants (N = 348) (comparator: large vessel distribution hemispheric stroke)
Intercept		0.286	0.073	0.0001
Variable tested	Brainstem	0.042	0.033	0.008
	Hemispheric lacune	−0.041	0.029
	Hemispheric hemorrhage	0.068	0.031
Control variables	Berg Balance Scale score	0.007	0.001	<0.0001
	Baseline gait speed	−0.187	0.073	0.0109
	Age	−0.003	0.001	0.0005
Model 2. Basal ganglia involvement, all participants with large vessel distribution infarcts (N = 150)
Intercept		0.446	0.103	<0.0001
Variable tested	Basal ganglia involved	−0.091	0.032	0.005
Control variables	Berg Balance Scale score	0.006	0.002	0.002
	Baseline gait speed	−0.187	0.126	0.141
	Age	−0.005	0.001	0.001
Model 3A. Effect of side of lesion potentially mediated by anosognosia/anosodiaphoria, all participants with large vessel distribution infarcts (N = 150)
Intercept		0.381	0.103	0.0003
Variable tested	Side (left)	−0.018	0.033	0.579
Control variables	Berg Balance Scale score	0.006	0.002	0.002
	Baseline gait speed	−0.174	0.130	0.183
	Age	−0.004	0.001	0.004
	Depression (PHQ-9 score)	−0.006	0.003	0.044
Model 3B. Effect of side of lesion and treatment interaction on effects potentially mediated by anosognosia/anosodiaphoria, all participants with large vessel distribution infarcts (N = 150)
Intercept		0.395	0.103	0.0002
Variables tested	Side (left)	−0.054	0.039	0.168
	Treatment (HEP)	−0.023	0.047	0.633
	Side × treatment	0.123	0.071	0.087
Control variables	Berg Balance Scale score	0.006	0.002	0.003
	Baseline gait speed	−0.149	0.130	0.254
	Age	−0.004	0.001	0.004
	Depression (PHQ-9)	−0.006	0.003	0.039
Model 4. Effect of side of lesion potentially mediated by disorders in perception of postural vertical, all participants with large vessel distribution infarcts (N = 150)
Intercept		0.557	0.104	<0.0001
Variables tested	Side (left)	−0.002	0.034	0.956
Control variables	Baseline gait speed	0.180	0.075	0.018
	Age	−0.006	0.001	<0.0001
Model 5. Effect of moderate to severe leukoaraiosis, all available participants (N = 347)
Intercept		0.326	0.072	<0.0001
Variable tested	Moderate to severe leukoaraiosis	−0.071	0.031	0.025
Control variables	Berg Balance Scale score	0.006	0.001	<0.0001
	Baseline gait speed	−0.157	0.073	0.033
	Age	−0.004	0.001	0.000
Model 6. Effect of old strokes, all available participants (N = 347)
Intercept		0.347	0.070	<0.0001
Variable tested	Old strokes present	−0.092	0.029	0.002
Control variables	Berg Balance Scale score	0.006	0.001	<0.0001
	Baseline gait speed	−0.162	0.073	0.026
	Age	−0.004	0.001	<0.0001