Table 2.
Frequencies of killer cell immunoglobulin-like receptor genes (KIR) and genotypes AA and Bx in studied groups
2DS1 | 2DS2 | 2DS3 | 2DS4f | 2DS4del | 2DS5 | 3DS1 | 2DL1 | 2DL2 | 2DL3 | 2DL5 | 3DL1 | Genotypes AA | Genotypes Bx | ||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
BD, n = 98 | n | 34 | 47 | 24 | 40 | 84 | 28 | 34 | 97 | 46 | 91 | 43 | 94 | 33 | 65 |
% | 34.69 | 47.96 | 24.49 | 40.82 | 85.71 | 28.57 | 34.69 | 98.98 | 46.94 | 92.86 | 43.88 | 95.92 | 33.67 | 66.33 | |
EU, n = 118 | n | 35 | 50 | 24 | 43 | 101 | 27 | 37 | 115 | 53 | 113 | 41 | 115 | 44 | 74 |
% | 29.66 | 42.37 | 20.34 | 36.44 | 85.59 | 22.88 | 31.36 | 97.46 | 44.92 | 95.76 | 34.75 | 97.46 | 37.29 | 62.71 | |
HIV+, n = 459 | n | 191 | 258 | 156 | 163 | 383 | 124 | 172 | 434 | 257 | 385 | 244 | 437 | 141 | 318 |
% | 41.61 | 56.21 | 33.99 | 35.51 | 83.44 | 27.02 | 37.47 | 94.55 | 55.99 | 83.88 | 53.16 | 95.21 | 30.72 | 69.28 | |
OR | 1.69 | 1.75 | 2.02 | 0.96 | 0.85 | 1.25 | 1.31 | 0.45 | 1.56 | 0.23 | 2.13 | 0.52 | 1.34 | ||
CI 95 % | 1.09 | 1.16 | 1.24 | 0.63 | 0.48 | 0.77 | 0.85 | 0.13 | 1.04 | 0.09 | 1.40 | 0.15 | 0.88 | ||
2.61 | 2.63 | 3.29 | 1.46 | 1.50 | 2.01 | 2.02 | 1.53 | 2.34 | 0.58 | 3.25 | 1.76 | 2.05 | |||
p* | 0.213 | 0.087 | 0.052 | 1.000 | 1.000 | 1.000 | 1.000 | 1.000 | 0.378 | 0.010 | 0.004 | 1.000 | 0.173 |
BD - blood donors from Lower Silesia region of Poland, EU - exposed, HIV-1-seronegative, HIV + - exposed to HIV and seropositive, 2DS4f - full-length KIR2DS4 gene, 2DS4del - KIR2DS4 with 22 base pair deletion, OR - odds ratio, based on the comparison of EU and HIV, CI 95 % - 95 % confidence interval, Bx - represents KIR genotypes AB and BB
*p value after Bonferroni correction (in case of comparison of KIRs frequencies)