Table 3.
Linkage disequilibrium (LD) analysis of 11 studied KIR genes in population background (BD, part A), HIV-positive (HIV+, lower triangle, part B), and exposed but uninfected individuals (EU, upper triangle, part B)
A | B | |||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
2DS1 | 2DS2 | 2DS3 | 2DS4 | 2DS5 | 3DS1 | 2DL1 | 2DL2 | 2DL3 | 2DL5 | 3DL1 | 2DS1 | 2DS2 | 2DS3 | 2DS4 | 2DS5 | 3DS1 | 2DL1 | 2DL2 | 2DL3 | 2DL5 | 3DL1 | |
D′ | 0.039 | 0.362 | −1.000 | 1.000 | 0.910 | 1.000 | 0.002 | −0.125 | 0.948 | −1.000 | 2DS1 | D′ | −0.056 | 0.171 | −1.000 | 0.842 | 0.750 | 1.000 | 0.015 | 1.000 | 0.650 | −1.000 |
r 2 | 0.001 | 0.080 | 0.080 | 0.753 | 0.828 | 0.005 | 0.000 | 0.002 | 0.610 | 0.080 | r 2 | 0.001 | 0.018 | 0.083 | 0.499 | 0.520 | 0.011 | 0.000 | 0.019 | 0.334 | 0.062 | |
0.760 | −0.039 | −0.032 | 0.039 | −1.000 | 1.000 | −1.000 | 0.285 | −0.039 | 2DS2 | −1.000 | 0.711 | 0.410 | −0.039 | 0.062 | −1.000 | 0.927 | −1.000 | 0.238 | 1.000 | |||
0.203 | 0.000 | 0.000 | 0.001 | 0.011 | 0.960 | 0.083 | 0.069 | 0.000 | 0.054 | 0.175 | 0.004 | 0.000 | 0.002 | 0.035 | 0.776 | 0.060 | 0.041 | 0.019 | ||||
−0.669 | 0.183 | 0.426 | 1.000 | 0.764 | −0.811 | 1.000 | −0.669 | 2DS3 | 0.374 | −0.328 | −0.372 | −0.272 | 0.332 | 1.000 | 0.773 | 0.017 | 0.681 | −0.163 | ||||
0.059 | 0.027 | 0.111 | 0.003 | 0.214 | 0.156 | 0.415 | 0.059 | 0.101 | 0.003 | 0.019 | 0.006 | 0.062 | 0.007 | 0.187 | 0.000 | 0.222 | 0.003 | |||||
−0.650 | −1.000 | −1.000 | −0.058 | 0.192 | −1.000 | 1.000 | 2DS4 | −0.178 | −0.295 | −0.376 | −0.676 | −1.000 | −1.000 | −0.092 | −1.000 | −1.000 | 1.000 | |||||
0.045 | 0.080 | 0.000 | 0.000 | 0.020 | 0.054 | 1.000 | 0.002 | 0.003 | 0.011 | 0.054 | 0.077 | 0.001 | 0.000 | 0.002 | 0.066 | 0.743 | ||||||
0.945 | 1.000 | −0.087 | 0.000 | 1.000 | −0.650 | 2DS5 | 0.931 | 0.245 | 0.059 | −0.839 | 0.892 | 1.000 | −0.010 | 1.000 | 0.830 | −1.000 | ||||||
0.673 | 0.004 | 0.003 | 0.000 | 0.512 | 0.045 | 0.450 | 0.017 | 0.003 | 0.073 | 0.517 | 0.008 | 0.000 | 0.013 | 0.384 | 0.088 | |||||||
1.000 | 0.002 | −0.125 | 0.948 | −1.000 | 3DS1 | 0.871 | 0.336 | 0.426 | −1.000 | 0.845 | 1.000 | 0.019 | −0.126 | 0.793 | −1.000 | |||||||
0.005 | 0.000 | 0.002 | 0.610 | 0.080 | 0.637 | 0.053 | 0.156 | 0.064 | 0.441 | 0.012 | 0.000 | 0.002 | 0.539 | 0.057 | ||||||||
−1.000 | 1.000 | 1.000 | −1.000 | 2DL1 | −0.452 | −0.635 | 0.647 | −1.000 | −0.233 | 0.253 | −1.000 | 1.000 | 1.000 | −1.000 | ||||||||
0.012 | 0.134 | 0.008 | 0.000 | 0.017 | 0.018 | 0.012 | 0.002 | 0.008 | 0.002 | 0.032 | 0.590 | 0.014 | 0.001 | |||||||||
−1.000 | 0.255 | −0.058 | 2DL2 | 0.298 | 0.929 | 0.854 | −0.465 | 0.230 | 0.326 | −0.636 | −0.637 | 0.203 | 0.258 | |||||||||
0.087 | 0.057 | 0.000 | 0.050 | 0.855 | 0.295 | 0.007 | 0.015 | 0.050 | 0.018 | 0.022 | 0.027 | 0.001 | ||||||||||
−0.745 | 0.192 | 2DL3 | −0.121 | −0.568 | −0.284 | 0.018 | −0.074 | −0.027 | 0.571 | −0.601 | −0.081 | −1.000 | ||||||||||
0.055 | 0.020 | 0.004 | 0.048 | 0.030 | 0.000 | 0.003 | 0.000 | 0.098 | 0.055 | 0.001 | 0.001 | |||||||||||
−1.000 | 2DL5 | 0.765 | 0.467 | 0.945 | −0.874 | 0.914 | 0.888 | 0.097 | 0.460 | −0.654 | −1.000 | |||||||||||
0.054 | 0.368 | 0.192 | 0.405 | 0.026 | 0.272 | 0.417 | 0.001 | 0.189 | 0.072 | 0.049 | ||||||||||||
3DL1 | −1.000 | −0.377 | −0.518 | 0.938 | −0.751 | −1.000 | −1.000 | −0.380 | 0.025 | −0.806 | ||||||||||||
0.071 | 0.006 | 0.026 | 0.672 | 0.077 | 0.084 | 0.003 | 0.006 | 0.000 | 0.029 |
Values marked in bold represent genes in significant LD
D’ - linkage disequilibrium value, r 2 - relative linkage disequilibrium value