Table 4.
Role of studied genetic factors in susceptibility to HIV infection
| Factors | Impacta | β | OR | CI 95 % | p value | vif | |
|---|---|---|---|---|---|---|---|
| CCR5-∆32 | ↓ | −1.398 | 0.25 | 0.09 | 0.68 | 0.006 | 3.394 |
| CCR2-64I | ↓ | −0.531 | 0.59 | 0.36 | 0.96 | 0.032 | 1.040 |
| KIR2DL3 | ↓ | −1.201 | 0.30 | 0.10 | 0.72 | 0.015 | 1.035 |
| KIR2DL5 | ↑ | 0.757 | 2.13 | 1.19 | 3.96 | 0.013 | 1.873 |
| KIR2DL2 in womenb | ↑ | 0.767 | 2.15 | 1.08 | 4.70 | 0.040 | 1.190 |
| KIR2DS1 in IDUc | ↑ | 1.109 | 3.03 | 1.21 | 8.13 | 0.022 | 3.486 |
| KIR3DS1 in IDUc | ↓ | −1.215 | 0.30 | 0.10 | 0.80 | 0.019 | 4.105 |
| CCR5-∆32 in IDUc | ↑ | 1.796 | 6.02 | 2.04 | 18.55 | 0.001 | 2.902 |
| CCR5-∆32 in womenb | ↓ | −1.212 | 0.30 | 0.10 | 0.86 | 0.026 | 1.860 |
| Intercept | – | 2.297 | – | – | – | 6.88e-06 | – |
All data come from one regression model including all factors listed in the Table 3. There was no collinearity between the variables (vif < 10.0)
↑ - infection risk increased, ↓- infection risk reduced, β - coefficient in regression model, CI 95- % 95 % confidence interval, OR - odds ratio, vif - variance inflation factor, IDU - intravenous drug users
aImpact on susceptibility to HIV infection
bCompared with men
cCompared with individuals sexually exposed to HIV