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. Author manuscript; available in PMC: 2016 Nov 15.
Published in final edited form as: Bioorg Med Chem. 2015 Oct 11;23(22):7119–7130. doi: 10.1016/j.bmc.2015.09.050

Table 3.

Drug Release Assay for NDCs

Substrate Trypsin
t1/2 a (min)		 Cathepsin B
t1/2 a (min)
C′dot-(Cy5)-PEG-Phe-Arg-dPEG2APdMG (6) 44 560
C′dot-(Cy5)-PEG-Phe-Lys-PABC-APdMG (7) 6 510
a

Time when 50% of the drug is released from linker or particle. Determined by HPLC.