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(A) Rnd3 is involved in apoptosis through ROCK1-dependent and –independent manners. (B) The ROCK1-dependent mechanism refers to that Rnd3 attenuates apoptosis through direct inhibition of ROCK1 activation. (C) The ROCK1-independent mechanism means that Rnd3 is involved in apoptosis through mediation of caspase3, BAX, Rb, plaloglobin, and BCL-2.
