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. Author manuscript; available in PMC: 2016 Dec 15.
Published in final edited form as: Compr Physiol. 2015 Dec 15;6(1):169–186. doi: 10.1002/cphy.c150018

Figure 6. Rnd3 involvement in overpressure-induced cardiomyocyte apoptosis and heart failure.

Figure 6

After TAC surgery, full length 160 kDa ROCK1 was cleaved into 130 kDa pieces. This cleaved ROCK1 promotes cardiomyocyte apoptosis and therefore leads to heart failure. Fasudil, a chemical inhibitor of ROCK1, attenuates TAC-promoted apoptosis and heart failure. Rnd3, the endogenous ROCK1 inhibitor, may directly attenuate ROCK1-induced apoptosis and may also inhibit apoptosis through a ROCK1-indendent manner, however, it remains unknown. For more details, please refer to our published articles; ref. (20) and (147).