. Author manuscript; available in PMC: 2016 Dec 15.

Published in final edited form as: Compr Physiol. 2015 Dec 15;6(1):169–186. doi: 10.1002/cphy.c150018

Table 4.

Aberrant Rnd3 expression functions through ROCK1-dependent and –independent manners

ROCK1-dependent mechanism	Physiological and pathological conditions
Cell polarity	CNS development, cell migration
Cell contraction	Pregnancy and habitual abortion, asthma
Apoptosis	Heart failure

ROCK1-independent mechanism	Physiological and pathological conditions

Cell proliferation (Notch1)	Hydrocephalus, tumor
Ca ²⁺ leakage (β₂AR/PKA)	Arrhythmias
Apoptosis (BAX, BCL-2, Rb, etc.)	Heart failure, tumor
Chemoresistance (BAX)	Tumor
Cell cycle arrest (cyclin D, cyclinB1, p21) Cell differentiation (Notch1, etc.) EMT	Tumor Myoblast infusion, somite formation Tumor metastasis
-	Endometriosis

EMT: Epithelial-mesenchymal transformation.