Fig. 6.

Forest plot of unadjusted odds ratios (ORs; 95% confidence intervals [CIs]) for major bleeding after primary percutaneous coronary intervention in patients with ST-elevation myocardial infarction undergoing radial artery access (RA) compared with femoral artery access (FA). A total of 107,208 patients were analyzed for major bleeding, 4868 of whom (34.7%) underwent RA and 9158 (65.3%) underwent FA. Major bleeding was observed in a total of 432 patients (3.0%). RA was associated with a reduction in major bleeding as compared with FA (1.7% vs 3.8%, OR 0.38, 95% CI 0.26–0.57, P < 0.001), similarly in both randomized controlled trials (1.9 % vs 4.7%, OR 0.45, 95% CI 0.29–0.70, P < 0.001) and cohorts (1.6% vs 3.6%, OR 0.31, 95% CI 0.16–0.59, P < 0.001).