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. Author manuscript; available in PMC: 2017 May 1.
Published in final edited form as: Prog Retin Eye Res. 2016 Mar 24;52:22–46. doi: 10.1016/j.preteyeres.2016.03.001

Figure 10.

Figure 10

Effect of alpha A and alpha B crystallin overexpression on RGC survival injured by ONT. A. At day 7, RGC protective effect of alpha A (αA) and alpha B (αB) crystallin overexpression was about 40%. ONT (n=5) vs. ONT+αA (n=7), *P=0.004; ONT+EGFP (n=6) vs. ONT+αA (n=7), **P=0.003; ONT (n=5) vs. ONT+αB (n=6), *P=0.006; and ONT+EGFP (n = 6) vs. ONT+αB (n=6), **P=0.004. B. Approximately a 95% and 75% increase in the RGC survival mediated by αA and αB overexpression, respectively, was observed two weeks after ONT. ONT (n=9) vs. ONT+αA (n=8), *P=0.001; ONT+EGFP (n=5) vs. ONT+αA (n=8), **P=0.003; ONT (n=9) vs. ONT+αB (n=8), *P=0.001; and ONT+EGFP (n=5) vs. ONT+αB (n=8), **P = 0.003. C. FG-labeled RGCs in nontransfected, EGFP, αA and αB transfected retinas two weeks after ONT.