Table 2.
Associations between WWOX CNV-67048 copy numbers and EOC risk and stages.
| CNV-67048 genotypes | n (%) | n (%) | P | Crude OR (95% CI) |
Adjusted OR (95% CI)a |
|---|---|---|---|---|---|
| Case-control study | Patients | Controls | |||
| Total number | 549 | 571 | |||
| 2-copy | 339 (61.75) | 397 (69.53) | 0.005 | 1.000 (ref.) | 1.000 (ref.) |
| 1-copy | 181 (32.97) | 160 (28.02) | 1.325 (1.024–1.714) | 1.268 (0.967–1.663) | |
| 0-copy | 29 (5.28) | 14 (2.45) | 2.425 (1.261–4.665) | 2.198 (1.111–4.348) | |
| 1 + 0-copy | 210 (38.25) | 174 (30.47) | 1.413 (1.103–1.811) | 1.346 (1.037–1.747) | |
| Trend test P value | 0.002 | 0.009 | |||
|
| |||||
| Case only study | Stages III + IV | Stages I + II | |||
| Total number | 506 | 43 | 0.308 | ||
| 2-copy | 309 (61.07) | 30 (69.77) | 1.000 (ref.) | 1.000 (ref.) | |
| 1-copy | 168 (33.20) | 13 (30.23) | 1.255 (0.637–2.470) | 1.330 (0.655–2.701) | |
| 0-copy | 29 (5.73) | 0 (0.00) | — | — | |
| 1 + 0-copy | 197 (38.93) | 13 (30.23) | 1.471 (0.749–2.888) | 1.554 (0.771–3.129) | |
| Trend test P value | 0.129 | 0.112 | |||
aAdjusted in a logistic regression model that included age, age at menarche, number of births, menstrual history, oral contraceptive use, family history of cancer, smoking status, and alcohol intake.